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IL-2 is a natural killer cell growth factor that is now also being used successfully in the treatment of metastatic melanoma. IL-2 therapy has also been shown to be active against CTCL. It acts by stimulating the production of cytotoxic lymphocytes. Given the well-documented activity of IL-2 therapy in CTCL, the IL-2 receptor has been identified and is being used to develop a molecular genetic strategy to deliver IL-2 directly to the malignant cells. The strategy of targeted IL-2 gene therapy relies upon the development of vectors (called IL-2-Gold particles) with which it is possible to replace a normally essential receptor function in the target cells. Such vectors will be based on a fusion gene, called IL-2ptrl, in which the IL-2 receptor gene is linked to a promoter that will direct expression in a wide variety of cells. 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For more information, please visit: Mac® is a registered trademark of Apple Inc. in the U.S. and other countries. Android™ is a registered trademark of Google Inc. in the U.S. and other countries. All other trademarks are
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